Fisiologia Renal de Vander – Ebook download as PDF File .pdf) or read book online. Conciso e didático, este livro explora os aspectos fundamentais da fisiologia renal que são essenciais para o bom entendimento da medicina clínica. : FISIOLOGIA RENAL DE VANDER 6TA. EDIC. by EATON DOUGLAS C. () by Douglas C. Eaton and a great selection of similar.
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Rennke H, Denker B.
Even nowadays the limits that separate the changes considered fisiologua of the normal ageing process of those patients who suffer from high prevalent illnesses characteristic of this period are not clear. The goal of his research is to examine the cellular signaling mechanisms which control all aspects of cellular function including cell growth, division, and responses to external stimuli.
Furosemide intravenous infusion furosemide test shows that fractional excretion of sodium FENa post-furosemide infusion is significantly lower in the very old group in comparison with the young one: Even though, the above mentioned creatinine renal filtration difference between the age groups, there is no significant difference regarding their serum creatinine value between them.
National Center for Biotechnology InformationU. Additionally, the high vvanders urinary excretion documented in the very old could be one of the factors which explains the senile medullar hypotonicity reduced urea medullar content and the nocturia urea osmotic diuresis usually found in the very old patients[ 1516 ]. Anatomical changes in the aging kidney. Creatinine reabsorption by the aged kidney.
Examination of kidney function. Aging and physiological changes of the kidneys including changes in glomerular filtration rate. Renal handling of uric acid, magnesium, phosphorus, calcium, and acid base in the elderly.
The procurement of a ratio between the CC and the CCWC allows for the evaluation of the net tubular handling of this substance: Renal handling of sodium in old people: Creatinine clearance measured without CC or with cimetidine CCWCwhich is almost the same as inuline clearance due to the blocking effect that cimetidine has on the proximal tubular secretion of creatinine, has proved to be significantly lower in the very old healthy people in comparison to that documented on the younger population[ 12 ]: Additionally, it has also been documented a decrease in sodium reabsorption in the thick ascending loop of Henle in very old healthy people[ 20 ].
Additionally, it is important to point out that there are no significant physiological differences related to gender in both age populations. Regarding tubular sodium handling in the oldest old, it has been documented that the selective reabsorption of sodium at the proximal tubule, evaluated using the Chaimowitz test, shows that it remains in the normal range: This article has been cited by other articles in PMC.
Clinical consequences[ 13 ]: Since furosemide stimulates sodium loss due to the inhibition of its reabsorption at the level of the TALH, the lower increase in soduria after furosemide infusion in the very old in comparison with the young could be explained by the functional reduction in the TALH furosemide blocking site due to the senescence process[ 23 – 25 ].
Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old
Since uric acid is mainly handled in the proximal tubule, a segment that suffers rena, no functional changes with ageing, perhaps this could explain the above mentioned phenomenon[ 14 ].
Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. All physiological genal of the aged kidney are the same in both genders. Dysfunction of the thick loop of Henle and senescence: Begins with the basics and works up to advanced principles Focuses on the logic of renal processes Includes the most current research on the molecular and genetic principles underlying renal physiology Explains the relationship between blood pressure and renal function Presents the normal functions of the kidney with clinical correlations to disease states Includes study questions with an answer key at the end of each chapter Features learning aids such as flow charts, diagrams, key concept clinical examples, boxed statements to emphasize major points, fisiologka objectives, and review questions with answers and explanations About the Authors Doug Eaton is the Distinguished Professor and Chairman of Physiology at Emory University.
Feed-back between geriatric syndromes: All authors contributed to this manuscript.
Fisiología renal de Vander – Douglas C. Eaton, John P. Pooler – Google Books
Tel 91 99 99 Fax 91 21 Physiology of the healthy ageing kidney. Martinus Nijhoff Publisher; The aging kidney in health and disease. Published online Oct 6. The observed difference in the creatinine filtration between the studied age groups could be justified as a consequence of the decrease in the number of glomerular units secondary to their obliteration due to the glomeruloscrerosis which accompanies ageing[ 3 – 5 ].
Combining the latest research with a fully integrated teaching approach, the eighth edition of Vander’s Renal Physiology features revised sections that explain how the kidneys affect other body systems and how they in turn are affected by these systems.
Fisiologia Renal de Vander
Renal reserve in the oldest old. Something similar was documented in the newborns but in this case it was attributed to tubular immaturity since this finding disappeared as they grew older[ 89 ].
Fractional excretion of urea in severely dehydrated elderly with dementia. This lower local sodium reabsorption, leads to the following alterations[ 8 ]: These finding could be interpreted as the fact that the dehydration over expresses the habitual senile creatinine back-filtration.