Bergenia ligulata is a perennial herb with short, thick, fleshy and procumbent stems and very stout root stock. Leaves are ovate or round and cm long. Bergenia ligulata wall whole plant is used for kidney and bladder stones, urinary problems. (8,9,) It has been reported to exhibit various pharmacological. Pashanabheda- Bergenia ligulata (Wall.) Engl. is a small plant used in the treatment of renal calculi, retention of urine, wounds, diseases of the.

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Journal of Economic and Taxonomic Botany ; Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders. Diuretic activity of B. When bergenin was incubated into hepatocyte medium for 14 hrs with 1.

Low doses of B. Administration of ethylene glycol 0. It reduced the elevated blood sugar in diabetic rats.

Nanda medicinal plants exports, located at Mansari, Kullu H. The microscopic evaluation revealed that the urine of mother extract, DCM fraction, and Neeri treated group rats was having lower number of crystals as compared to urolithiasis rat Figure 5.

After urine collection, total urinary excretion of calcium, phosphate, oxalate, uric acid, and albumin was measured by various biochemical kits Span Diagnostics Ltd.

The supernatant was subjected to analysis for calcium, oxalate, uric acid, and phosphate ligultaa using various biochemical kits Span Diagnostics Ltd. Ligulaata is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is listed as a threatened or endangered and vulnerable medicinal plant using new IUCN criteria In summary, it was demonstrated that B. Before every experiment, a prealignment of the microscope was carried out and the focus adjusted to ligulaya interface between glass and reaction solution.

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ligulataa Indian Journal of Experimental Biology ; The antiurolithiasis activity of mother extract and the best bioactive fraction of B.

No significant changes were observed in the sham control group as compared to normal control rat, indicating no adverse effect. View at Google Scholar F. Extracts and molecules from medicinal plants against herpes simplex viruses. Other activities Alcoholic extract of B.

Antiurolithic effect of Bergenia ligulata rhizome: These above changes induce the hyperoxaluria and succeeding crystal adherence and retention in renal tubules [ 26 ].

The growth of crystals was expected due to the following reaction: Mother extract and DCM fraction treatment resulted in a reduction of the degenerative changes in the kidney tissue like interstitial infiltration of the inflammatory cell, epithelial cell dissociation, and proximal tubules dilation Figure 6 d.

In vitro studies on antilithiatic activity of seeds of Dolichos biflorus Linn. Establishment of protocols for in-vitro culture and micropropogation of this endangered but clinically potential candidate is the need of hour.


The in vitro, ex vivo, and real-time antiurolithiasis activity of mother extract and fractions were carried out using aggregation assay in hergenia urine and in rat plasma.

Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms.

Similarly, no changes have been observed in the spleen of sham and normal control rat. CRC Press Inc; New York Science Journal ;2: In Vivo Evaluation 2. Indian Journal of Pharmacology ;4: Phytochemical and anti-inflammatory investigations of Bergenia ligulata.

The microscopic evaluation of collected urine was done at 10x magnification. Histopathological evaluation of kidney through microscopic examination showed accumulation of calcium oxalate deposits inside litulata tubules in calculi-induced animals.

Bergenia ligulata – Wikipedia

In vitro and ex vivo studies will be the new approach for determination of antiurolithiasis potential, which can be used for other drugs as well. These data indicated the antiurolithic activity of B.

Free radical scavenging activity Methanolic extract of B. It is unlikely that these effects will be encountered with the doses in clinical use. Phytochemical evaluation and free radical scavenging properties of rhizome of Bergenia ciliate. Bergenia Moench- elephant ear Species: Journal of Oleo Science ;