L’ormonorefrattarietà del carcinoma prostatico è un evento multifattoriale ed i tradizionali (adriamicina, alcaloidi della vinca, etoposide, cioclofosfamide). Gli alcaloidi della vinca rosea: tesi di laurea. Front Cover. Riccardo Ramacciotti Bibliographic information. QR code for Gli alcaloidi della vinca rosea. Farmacologia degli alcaloidi della vinca: attività antitumorale della vinorelbina: tesi di laurea. Front Cover. Marco Bertoni. – pages.

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Polymer—enzyme liposome therapy PELT relies on the liberation of drug from liposomes by the action of a polymer—phospholipase conjugate. In the absence of drugs, dynamics are fast, with many length changes.

Treadmilling is brought about by the different tubulin critical concentrations at the opposite ends. Polymers that are conjugated to membrane active peptides or drugs that are known to activate the apoptosis pathway also have the potential to act at the level of the plasma membrane.

To make this website work, we log user data and share it with processors. Nucleation is followed by elongation of the microtubule at both ends to form a cylinder that is composed of tubulin heterodimers arranged head-to-tail in 13 protofilaments.

Alcaloides de la vinca

In the presence of a drug such as paclitaxel, dynamics are suppressed. Ultimately, the Pi dissociates from the microtubule, leaving a microtubule core consisting of tubulin with stoichiometrically bound GDP.


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Five possible outcomes of antimitotic drug treatment at the cellular level, derived from cultured cell studies. Polymer-directed enzyme prodrug therapy PDEPT is a two-step approach that relies on activation of a polymer—drug conjugate by a complementary polymer—enzyme conjugate.

Farmaci Antimitotici.

Subsequently, numerous molecules have been studied so far and other are being analysed, on patients with hormone-refractory cancer, in particular two, Cabazitaxel and Abiraterone acetate have demonstrated a good toxicity profile and activity, providing both an improvement in the quality of life and survival rate in patients who have showed disease progression after chemotherapeutic treatment with taxanes.

Mol Cancer Ther ;5: Autorizzarsi attraverso i social network: Scaricare ppt “Farmaci Antimitotici. Copiare nel buffer di scambio. Disease progression can be determined by apcaloidi PSA increase, symptoms decline or organ progression for which there is existing research evidence. Pubblicato Brizio Raimondi Modificato 4 anni fa.

Tubulin heterodimers are added at the plus end of the microtubule at time 0, treadmill through the microtubule and are lost from the minus end of the microtubule at time 3. Modified from Weaver and Cleveland Vol 18 No 1 Once present in the tumour interstitium, polymer therapeutics act either after endocytic internalization or extracellularly.

For many years hormone-refractory prostate cancer has been treated with a palliative treatment of steroids, second-line hormone therapy or traditional chemotherapeutic cures Adriamycin, vinca alkaloids, etoposide, cyclophosphamide.


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Hormone-refractory prostate cancer is a multifactor event and patients suffering from hormonerefractory prostate cancer have a median survival rate of 12 months. Changes in length at the plus ends are greater than at the minus ends. Also shown is the use of bioresponsive, endosomolytic polymers to facilitate cytosolic access of genes and proteins from the endosome. From to the second therapeutic approach was represented by Taxanes which demonstrated, in two different studies, the capability of improving survival.

The length of the microtubule is unchanged. Feed-back Privacy Policy Feed-back. Structures of the epothilones that are furthest along in clinical development.

To use this website, you must agree to our Privacy Policyincluding cookie policy. Le mie presentazioni Profilo Feed-back Uscire. Hyperpermeable angiogenic tumour vasculature allows preferential extravasation of circulating macromolecules and polymeric micelles. The microtubules were assembled from purified bovine brain tubulin and the changes in length were traced by differential interference-contrast alccaloidi microscopy.